Delivery

LSC has demonstrated that Hydroxysomes™ can penetrate into Stratum corneum [Sc] without disruption of the integrity of the skin.

The Hydroxysomes™ delivery technology offers many advantages over currently available polymer- and liposome-based delivery systems. It is applicable to many classes of hydrophilic and lipophilic bioactive molecules; is tunable, non-toxic and biodegradable.  Moreover, Hydroxysomes™ can be loaded with bioactives at high capacity.  The technology can be adapted for each new bioactive without extensive formulation development.

Confocal Microscopy 300 x
Chlortetracycline – Hydroxysomes™ delivered into Sc, fluorescence shown in purple

The high surface area and nanoporous structure of Hydroxysomes™ allow it to adsorb, carry and subsequently release the bioactives into the Sc. For the exact release mechanism and delivery to receive propriety information, please contact us.

TEM 27,000x
No calcium ions are detected in the Sc before application of Hydroxysomes™

TEM 43,000x
After topical application, Hydroxysomes™ can be seen in the Sc, traversing into the deeper layers.