Binding-Attachment

Hydroxysomes™ binds a broad range of bioactives and can potentially stabilize them for dermal delivery.  Its nanoporous structure gives it a large internal and external binding surface area. Binding to Hydroxysomes™ is based on ionic interactions. The attachment can be selective based on the characteristics of each bioactive and the pH.

For example when binding to proteins the calcium ions of Hydroxysomes™ can bind to the carboxyl groups, and the phosphate ions of Hydroxysomes™ can bind to the amino groups.

In addition to pH and ionic strength, the molecular weight and the stoichiometry of biomaterials also influence the binding to Hydroxysomes™

Potential Actives for Attachment:

Lipophilic Actives

• Vitamins                       
• Fatty Acids   
• Phospholipids          
• Retinoids                       
• Steroids                       
• Other Lipophilic Actives   

Hydrophilic Actives  

• Proteins    
• Peptides
• Nucleic Acids
• Carbohydrates
• Polysaccharides    
• Other Hydrophilic Actives